The gang at the Pulp Gamer podcast tackle Mutant City Blues, GUMSHOE and much more in episode 192. Jason dropped the linked, explicable super powers of the default game setting in favor of the Marvel universe’s jam-packed cavalcade of weirdness, and still got the premise to work.
As I point you to the episode, I do have to pipe up with a small correction. There’s a touch of mis-speaking in the segment, giving the impression that you have to pay investigative points to get core clues in GUMSHOE. Readers familiar with the game already know that investigative point spends only occur to get cool but tangential information or other tangible benefits. Core clues are always available without a spend, fulfilling the game’s purpose of eliminating investigative logjams.